Yes, I've not tested it deeply because I haven't Vista but it works ok. If you'll find any problem please let me know. Be sure to download the latest revision of version 3.3.
I have Vista and at first it didn't want to download, but I had two options to click - Cancel, which was recommended, and Ignore (there was a third option but I forgot what it is). I first cancelled and was very disappointed, but then tried again and chose Ignore. Now I've got D.H.E. (1.9) on Vista and it works perfectly fine. :-)